The leading human rights organization for all individuals with Down syndrome.

National Down Syndrome Society
8 E 41st Street, 8th Floor
New York New York 10017
[email protected] 


National Down Syndrome Society
8 E 41st Street, 8th Floor
New York, NY 10017

Dear Friend,

Thank you for choosing to make a charitable donation to the National Down Syndrome Society. We rely on the support from compassionate and committed donors, like you, for the resources to preserve our mission.

Since its founding in 1979, NDSS has been a leader in the Down syndrome community and continues to be the national advocate for the value, acceptance and inclusion of people with Down syndrome.

The National Down Syndrome Society envisions a world in which all people with Down syndrome have the opportunity to enhance their quality of life, realize their life aspirations, and become valued members of welcoming communities.

To those of you who have supported NDSS in the past, thank you. I hope that you will continue your generosity towards our cause and mission. To those who may be first-time donors, I urge you to explore our website to learn about the many successful achievements of NDSS and the new initiatives we have currently commissioned.

Our biannual appeal letters highlight individuals in our community who are taking full advantage of our programs and who are helping NDSS strengthen its vision. We encourage you to read about some of our advocacy efforts, our younger self-advocates, Sheridan, Kadin and Avery, and some of our wonderful DS-Ambassadors.

NDSS Your Way is our fundraising initiative that brings together donors' individual campaigns with NDSS support staff. It is an online program geared towards independent fundraisers interested in raising money on behalf of the National Down Syndrome Society (NDSS).

Your support for the Down syndrome community is greatly appreciated.


Sara Hart Weir
NDSS President

Ways to Donate:


Online donations to NDSS are easy and secure.

Make an online donation.

By Phone

Please call the toll-free NDSS helpline at 800-221-4602, Monday - Friday, 9am-5pm ET to make a donation by phone.

By Mail or Fax

Please download the donation form and enclose with your donation. Mail or fax the completed form to:

National Down Syndrome Society

8 E 41st Street, 8th Floor

New York, NY 10017

Fax: 212-979-2873

Please note, the National Down Syndrome Society is a registered 501(c)(3) nonprofit organization. All donations of $250 or more will receive a letter of acknowledgment for tax purposes. For donations under $250, your cancelled check or credit card statement serve as your receipt.

  • Buddy Walk
  • NDSS Yourway
  • NDSS DS-Ambassadors