The National Advocate for People with Down Syndrome Since 1979

National Down Syndrome Society
666 Broadway, 8th Floor
New York New York 10012

NDSS 3:21 Signature Clothing Line

World Down Syndrome Day is celebrated on March 21 to symbolize the third copy of the 21st chromosome that charaterizes Down syndrome. World Down Syndrome Day is the perfect time to wear the NDSS 3:21 signature clothing line by Rhyme & Reason. The signature line features 3:21 on the front and the NDSS logo on the back. For each signature shirt purchased, $5 will be donated to NDSS.

The yellow t-shirt design is now available for men, women and kids. The adult line offers a grey t-shirt for men, and grey and navy t-shirts for women. Sweatshirts are available in blue for men and raspberry and coral for women. Slip into these super soft designs and spark a conversation about Down syndrome this March 21!

Visit the Rhyme & Reason website to view the collection and make a purchase. Orders received by March 14 will be delivered in time for March 21. For each item you buy that isn't part of the signature line, Rhyme & Reason will donate 10% to NDSS when you select National Down Syndrome Society at checkout.

Check out this year's 3:21 t-shirt video! Thank you to all who shared their photos.


NDSS Resources

  • Buddy Walk
  • NDSS Yourway
  • My Great Story
  • NDSS DS-Ambassadors